Fragile X syndrome is the most common Xlinked genetic disorder associated with MR with a prevalence of around 1 in 1250 males and 1 in 2500 females. (Sherman et al. 1985; Hagerman 1992). Fragile X chromosome derives its name from the characteristic appearance of hypochromatic constriction at the tip of X chromosome at Xq 27.3 locus and it is visualized in the cells cultured in folic acid deficient medium (Sutherland 1979c). Most of the Fragile X patients show triad of clinical features, viz., MR, triangular face and macro-orchidism Fragile X syndrome has been reported by several groups from many countries and from different ethnic population. Click here to read more…
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